Semisynthesis and cytotoxicity of styryl-lactone derivatives

Authors
Bermejo, A Leonce, S Cabedo, N Andreu, I Caignard, DH Atassi, G Cortes, D
Citation
A. Bermejo et al., Semisynthesis and cytotoxicity of styryl-lactone derivatives, J NAT PROD, 62(8), 1999, pp. 1106-1109
Citations number
19
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
8
Year of publication
1999
Pages
1106 - 1109
Database
ISI
SICI code
0163-3864(199908)62:8<1106:SACOSD>2.0.ZU;2-I
Abstract
The cytotoxicity and the cell-cycle action of altholactone (1), goniofufuro ne (2), and eight altholactone derivatives. (5-12), were determined in vitr o on L-1210 cells. Semisyntheses and structure-activity relationships of th ese compounds are described. The results of this study suggest that the cyt otoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7- dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.