Citation
R. Niero et al., Antinociceptive activity of niga-ichigoside F-1 from Rubus imperialis, J NAT PROD, 62(8), 1999, pp. 1145-1146
Citations number
12
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864
→ ACNP
Volume
62
Issue
8
Year of publication
1999
Pages
1145 - 1146
Database
ISI
SICI code
0163-3864(199908)62:8<1145:AAONFF>2.0.ZU;2-N
Abstract
This work describes the antinociceptive effect of a triterpene glycoside, n
iga-ichigoside F-1 (1), obtained from an EtOAc extract of the aerial parts
of Rubus imperialis. When evaluated against an HOAc-induced writhing model,
it exhibited an ID50 value of 3.1 mg/kg (ip). Moreover, in a formalin-indu
ced pain model, both phases of pain were inhibited by compound 1, with ID50
values of 2.6 (first phase) and 2.7 (second phase) mg/kg, (ip), respective
ly.