Isolation of two highly methylated polyketide derivatives from a yew-associated Penicillium species

Authors
Stierle, DB Stierle, AA Ganser, BK
Citation
Db. Stierle et al., Isolation of two highly methylated polyketide derivatives from a yew-associated Penicillium species, J NAT PROD, 62(8), 1999, pp. 1147-1150
Citations number
11
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
8
Year of publication
1999
Pages
1147 - 1150
Database
ISI
SICI code
0163-3864(199908)62:8<1147:IOTHMP>2.0.ZU;2-L
Abstract
Two selective antifungal agents were produced by a Penicillium sp. isolated from the inner bark of the Pacific yew tree, Taxus brevifolia. The structu res of these highly methylated polyketide derivatives were deduced by detai led analysis of both 1D and 2D NMR and difference NOE spectra. Both compoun ds were active against the plant pathogen, Sclerotinia sclerotiorum in the standard disk assay.