Mj. Drian et al., In vitro neuroprotection against glutamate toxicity provided by novel non-competitive N-methyl-D-aspartate antagonists, J NEUROSC R, 57(6), 1999, pp. 927-934
Primary cultures of embryonic cortical cells were used to test the neuropro
tective effect of two novel noncompetitive N-methyl-D-aspartate antagonists
against the neurotoxicity of glutamate, These two compounds, GK 11 and GK
222, are phencyclidine derivatives that contain asymetric carbon atoms. We
have tested the neuroprotective effects of the racemates as well as those o
f the corresponding plus and minus enantiomers and have compared them with
the reference drug dizocilpine (MK-801). We show here that the (-) enantiom
ers have a significantly better protective effect than the (+) enantiomers,
but that the former are as efficient as the corresponding racemates, Quali
tative analysis with different neuronal and glial markers does not reveal a
ny difference in the population of protected cells among the different mole
cules tested. (C) 1999 Wiley-Liss, Inc.