POLYMER-SUPPORTED QUENCHING REAGENTS FOR PARALLEL PURIFICATION

The preparation of polystyrene-divinylbenzene-supported derivatives of tris(2-aminoethyl)amine and methyl isocyanate are described. These po lymeric reagents are used to quench excess reactants and remove known impurities from the crude reaction products obtained from the solution -phase, parallel syntheses of ureas, thioureas, sulfonamides, amides, and pyrazoles. In conjunction with the use of other polymeric reactant s during the course of a reaction, the addition of polymer-supported q uench reagent(s) at the conclusion of the reaction allows isolation of the desired product by a single filtration and evaporation of solvent . The mechanical simplicity and efficiency of this methodology make po ssible the rapid, parallel purification of crude reaction products obt ained via solution-phase syntheses, regardless of whether the intended product is a single compound or a mixture of compounds, and hence off ers an attractive alternative to solid-phase organic synthesis in the practice of combinatorial chemistry.