Background: Numerous factors may impede the delivery of enteral tube feedin
gs (ETF) in the intensive care unit (ICU). We designed a prospective study
to determine whether the use of an infusion protocol could improve the deli
very of ETF in the ICU. Methods;: In a prior prospective study, we monitore
d all patients admitted to the medical intensive care unit (MICU) or cardia
c care unit (CCU) who were made nit per os and placed on ETF (control group
). We found that critically ill patients received only 52% of their goal ca
lories, primarily due to physician underordering (66% of goal), frequent ce
ssations of ETF (22% of the time), and slow advancement (14% at goal by 72
hours). Based on these findings, we developed an ETF protocol that incorpor
ated standardized physician ordering and nursing procedures, rapid advancem
ent, and limited ETF interruption. After extensive educational sessions, th
e ETF protocol was begun. Again, all patients admitted to the MICU or CCU w
ho were made nit per os and placed on ETF were prospectively followed (prot
ocol group). Results: Thirty-one patients in the protocol group were follow
ed during 312 days of ETF and compared with the control group (44 patients
with 339 days of ETF). Despite efforts by the nutritional support team, the
infusion protocol was used in only 18 patients (58%). The main reasons for
noncompliance with the protocol were physician preference and system failu
re (ETF order sheet not placed in chart). When used, the infusion protocol
improved physician ordering (control 66% of goal volume, noncompliant 68%,
compliant 82%, p <.05); delivery of calories (control 52% of goal, noncompl
iant 55%, compliant 68%, p <.05); and advancement of ETF (control 14% at go
al by 72 hours, noncompliant 31%, compliant 56% ,p <.05). Although signific
ant reduction in ETF cessation due to nursing care was noted, it represente
d only a fraction of the total time ETF were stopped. Cessation due to resi
dual volumes, patient tolerance, and procedure continued to be a frequent o
ccurrence and was often avoidable. Conclusions: An evidence-based infusion
protocol improved the delivery of ETF in the ICU, primarily because of bett
er physician ordering and more rapid advancement. The nursing staff rapidly
assimilated these changes. However, physicians' reluctance to use the prot
ocol limited its efficacy and will need continued educational efforts.