Interleukin-11: Its biology and prospects for clinical use

Authors
Grosfeld, JL Du, XX Williams, DA
Citation
Jl. Grosfeld et al., Interleukin-11: Its biology and prospects for clinical use, J PARENT EN, 23(5), 1999, pp. S67-S69
Citations number
19
Categorie Soggetti
Endocrynology, Metabolism & Nutrition
Journal title
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
ISSN journal
01486071 → ACNP
Volume
23
Issue
5
Year of publication
1999
Supplement
S
Pages
S67 - S69
Database
ISI
SICI code
0148-6071(199909/10)23:5<S67:IIBAPF>2.0.ZU;2-J
Abstract
IL-11 is a multifunctional cytokine that has pleiotropic effects on a varie ty of tissue including the bone marrow and intestinal mucosa. IL-11 is usef ul in elevating the platelet count in cancer patients with chemotherapy-ind uced thrombocytopenia and has a cytoprotective effect on the bowel mucosa i n a variety of causes of gut damage and a trophic effect on the villi after massive bowel resection.