SYNTHESIS OF A SERIES OF HOMOPTEROCARPANE DERIVATIVES WITH POTENTIAL ANTITUMOR AND ANTI-AIDS ACTIVITY

Authors
VALENTI P FABBRI G RAMPA A BISI A BELLUTI F
Citation
P. Valenti et al., SYNTHESIS OF A SERIES OF HOMOPTEROCARPANE DERIVATIVES WITH POTENTIAL ANTITUMOR AND ANTI-AIDS ACTIVITY, Il Farmaco, 52(1), 1997, pp. 13-19
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
52
Issue
1
Year of publication
1997
Pages
13 - 19
Database
ISI
SICI code
0014-827X(1997)52:1<13:SOASOH>2.0.ZU;2-8
Abstract
The synthesis of a series of derivatives related to (+/-) cis 6a, 12a- dihydro-6H,7H-[1]-benzopy rano-[4,3-b]-[1]-benzopyran (Homopterocarpan e) is described. The synthesized derivatives have been tested al Natio nal Cancer Institute in its in vitro anti-cancer and anti-AIDS screeni ng programs. The synthesized compounds are inactive in anti-HN assay, while some show a GI(50)<100 mu M (and <50 mu M in several cell lines) in NCl antitumor screening.