P. Valenti et al., SYNTHESIS OF A SERIES OF HOMOPTEROCARPANE DERIVATIVES WITH POTENTIAL ANTITUMOR AND ANTI-AIDS ACTIVITY, Il Farmaco, 52(1), 1997, pp. 13-19
The synthesis of a series of derivatives related to (+/-) cis 6a, 12a-
dihydro-6H,7H-[1]-benzopy rano-[4,3-b]-[1]-benzopyran (Homopterocarpan
e) is described. The synthesized derivatives have been tested al Natio
nal Cancer Institute in its in vitro anti-cancer and anti-AIDS screeni
ng programs. The synthesized compounds are inactive in anti-HN assay,
while some show a GI(50)<100 mu M (and <50 mu M in several cell lines)
in NCl antitumor screening.