SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF N-(1,2-BENZISOTHIAZOL-3-YL)AMIDINES

Several N-(1,2-benzisothiazol-3-yl)amidines were synthesized and exami ned for their in vitro antimicrobial activity. Some of the compounds s tudied were effective against bacteria and fungi. Amidines carrying un saturated alkylic chains showed the highest antimicrobial activity, th e propenyl derivative 7 proving to be the most potent with minimum inh ibitory concentrations of 25 mu g/ml against Gram positive bacteria an d mould and of 3-12 mu g/ml against yeasts. The results indicate that an unsaturated moiety is an important function for enhancing the antim icrobial activity in the compounds under investigation.