STEREOSELECTIVE SYNTHESES OF BETA-L-FD4C AND BETA-L-FDDC

Authors
CHEN SH LI XY LI J NIU CS CARMICHAEL E DOYLE TW
Citation
Sh. Chen et al., STEREOSELECTIVE SYNTHESES OF BETA-L-FD4C AND BETA-L-FDDC, Journal of organic chemistry, 62(11), 1997, pp. 3449-3452
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
62
Issue
11
Year of publication
1997
Pages
3449 - 3452
Database
ISI
SICI code
0022-3263(1997)62:11<3449:SSOBAB>2.0.ZU;2-S
Abstract
Stereocontrolled syntheses of two potent antiviral agents, beta-L-FD4C and beta-L-FddC, were accomplished both in 10-step sequences, with an overall yield of 27% and 25%, respectively. It is worthwhile to menti on that the introduction of a phenylseleno moiety to the C-2 alpha pos ition of the lactone 4 can now be performed in a stereocontrolled fash ion, providing the key intermediate 5 alpha in 75% yield.