REACTION OF NITRIC-OXIDE WITH AMINES

Reactions of nitric oxide (NO) with amines in organic solvents were st udied using Hantzsch dihydropyridines and aromatic primary amines as s ubstrates. Hantzsch dihydropyridines are readily oxidized by nitric ox ide to give the corresponding pyridines in quantitative yields. The ad dition of oxygen accelerates the reaction rate considerably. On the ot her hand, aromatic primary amines give deaminated products by the reac tion with nitric oxide only in the presence of oxygen in ethereal solv ents or chloroform.