STUDIES TOWARD LIPID-A - SYNTHESIS OF DIFFERENTIALLY PROTECTED DISACCHARIDE FRAGMENTS

Disaccharides containing two glucosamine units are readily synthesized where the two amine functionalities are orthogonally protected as the tetrachlorophthaloyl and pent-4-enoyl moieties. The 1-->6 linked disa ccharide has the potential to be developed toward a series of biologic ally interesting lipid A analogs.