A. De Simone et al., Pretreatment with verapamil in patients with persistent or chronic atrial fibrillation who underwent electrical cardioversion, J AM COL C, 34(3), 1999, pp. 810-814
Citations number
15
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
OBJECTIVES To evaluate, in a prospective and randomized fashion, the effica
cy of a pretreatment with verapamil (V) in reducing recurrences of atrial f
ibrillation (AF) after electrical cardioversion (C).
BACKGROUND The increased vulnerability for AF recurrence is probably due to
AF-induced changes in the electrophysiologic properties of the atria. This
electrical remodeling seems to be due to intracellular calcium overload.
METHODS One hundred seven patients with persistent or chronic AF underwent
external and/or internal C. All patients received oral propafenone (P) (900
mg/day) three days before and during the entire period of follow-up (three
months). In the first group, patients received only the P. In the second g
roup, in adjunct to P, oral V (240 mg/day) was initiated three days before
C and continued during the follow-up. Finally, in the third group, oral V w
as administered three days before and continued only for three days after e
lectrical C.
RESULTS During the three months of follow-up, 23 patients (23.7%) had AF re
currence. Mantel-Haenszel cumulative chi-square reached a significant level
only when comparing AF free survival curves of group I versus group II and
group III (chi-square 5.2 and 4, respectively; p < 0.05). Significantly, 1
5 (65.2%) AF relapses occurred during the first week after cardioversion wi
th a higher incidence in group I (10/33 patients, 30.3%) than group II (2/3
4 patients, 5.9%; p = 0.01) and group III (3/30 patients, 10%; p = 0.04).
CONCLUSIONS Six days of oral V administration centered on the C day, combin
ed with P, significantly reduce the incidence of early recurrences of AF co
mpared with P alone. CT Am Coil Cardiol 1999;34:810-4) (C) 1999 by the Amer
ican College of Cardiology.