Objective To evaluate published reviews of the appropriateness of prop
hylactic removal of impacted third molars. Design Systematic review an
d critical appraisal of relevant reviews. Methods Computerised databas
es (Medline and Embase), the Index to Dental Literature, and the refer
ences of articles were searched to identify relevant reviews. Main out
come measures Pathologies associated with impacted third molars and ou
tcomes following surgical removal of third molars. Results Twelve publ
ished reviews were assessed. Major methodological problems in these in
clude that authors did not describe review methods such as literature
search strategy and criteria for inclusion of primary studies. Reviews
with similar aims included different sets of primary studies as evide
nce. Details of primary studies quoted were seldom sufficient for read
ers to judge the reliability of the evidence. With the exception of tw
o reviews with poorer quality, the reviews concluded that there is a l
ack of evidence to support the prophylactic removal of impacted third
molars. Two decision analyses also concluded that, on average, patient
s' long-term wellbeing is maximised if extraction is confined to those
impacted third molars with pathology. Conclusions In the absence of g
ood evidence to support prophylactic removal, there appears to be litt
le justification for the removal of pathology-free impacted third mola
rs.