DORRIGOCINS - NOVEL ANTIFUNGAL ANTIBIOTICS THAT CHANGE THE MORPHOLOGYOF RAS-TRANSFORMED NIH 3T3 CELLS TO THAT OF NORMAL-CELLS .1. TAXONOMYOF THE PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY/

The dorrigocins are new, secondary metabolites produced by submerged f ermentation of a streptomycete which was isolated from a soil sample c ollected in Australia. The dorrigocins show moderate antifungal activi ty and reverse the morphology of ras-transformed NIH/3T3 cells from a transformed phenotype to a normal one. The producing culture was ident ified as Streptomyces platensis subsp. rosaceus strain AB1981F-75.