DORRIGOCINS - NOVEL ANTIFUNGAL ANTIBIOTICS THAT CHANGE THE MORPHOLOGYOF RAS-TRANSFORMED NIH 3T3 CELLS TO THAT OF NORMAL-CELLS .3. BIOLOGICAL PROPERTIES AND MECHANISM OF ACTION/

The dorrigocins are unique glutarimide antibiotics which were found to reverse the morphology of ras-transformed NIH/3T3 cells from a transf ormed phenotype to a normal one. The compounds also inhibited the rele ase of yeast mating pheromone, a-factor. The activity of these compoun ds was not dependent on inhibition of prenylation or protein synthesis . Dorrigocin A was instead found to inhibit the carboxyl methylation i n K-ras transformed cells.