STRUCTURES OF DNACIN A(1) AND B-1, NEW NAPHTHYRIDINOMYCIN-TYPE ANTITUMOR ANTIBIOTICS

Authors
HIDA T MUROI M TANIDA S HARADA S
Citation
T. Hida et al., STRUCTURES OF DNACIN A(1) AND B-1, NEW NAPHTHYRIDINOMYCIN-TYPE ANTITUMOR ANTIBIOTICS, Journal of antibiotics, 47(8), 1994, pp. 917-921
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
8
Year of publication
1994
Pages
917 - 921
Database
ISI
SICI code
0021-8820(1994)47:8<917:SODAAB>2.0.ZU;2-0
Abstract
Dnacin A(1) and B-1 were revealed to be new naphthyridinomycin-type an titumor antibiotics with formulae of C20H23N5O4 and C19H24N4O5, respec tively. The gross structure of dnacin A(1) was elucidated by the spect roscopic analyses. Conversion of dnacin B-1 into A(1) by treatment wit h potassium cyanide indicated the presence of an alpha-carbinolamine m oiety in dnacin B-1. The relative stereochemistry of dnacins was clari fied by analysis of the NOESY spectra.