Central nervous system relapse following bone marrow transplantation in stage IV neuroblastoma

Neuroblastoma is the most common extracranial solid tumor in pediatrics. Th e disease;free survival rate for patients with stage IV neuroblastoma has i mproved over the past 10 years secondary to more aggressive induction chemo therapy regimens combined with autologous bone marrow trans plantation. The usual sites of recurrence include the site of primary tumor; residual gros s disease, bone, a nd bone marrow The central nervous system, a rare site o f relapse, is being involved with increasing frequency. The authors report two cases of patients with treated stage IV neuroblastoma who had relapses isolated to the CNS.