Venous thromboembolism, factor V Leiden, and methylenetetrahydrofolate reductase in a sickle cell anemia patient

Vaso-occlusive crisis is the most common cause of morbidity in patients wit h sickle cell anemia (SCA). Central nervous system involvement that leads t o hemiplegia is the most frequent neurological complication in those patien ts. Peripheral deep venous thromboembolism was not reported in SCA patients . Activated protein C resistance is associated with an increased risk of th rombophilia. The authors report an SCA patient with recurrent cerebrovascul ar accident and deep venous thrombosis. Activated protein C resistance due to factor V Leiden heterozygous and heterozygocity for the methylenetetrahy drofolate reductase were diagnosed and suspected to be the risk factors tha t contribute to the development of the deep vein thrombosis in this SCA pat ient.