Dose confirmation study of a 10g liter(-1) non-aqueous injectable formulation of moxidectin against naturally acquired infestations of cattle lice oncattle in New York

This study demonstrated that a moxidectin 10g liter(-1) non-aqueous injecta ble formulation, injected subcutaneously in cattle at a dose of either 0.2 or 0.3 mg moxidectin kg(-1) body weight was safe and highly effective in th e almost complete elimination (>99% efficacy) for 56 days of both the nymph al and adult stages of naturally acquired infestations of the three species of sucking lice commonly found on cattle, Haematopinus eurysternus (Nitzsc h), Linognathus vituli (L), and Solenopotes capillatus (Enderlein). The lev el of efficacy was never greater than 90% with either dose against Bovicola bovis (L). No adverse effects were noted on cattle from either of the moxi dectin doses used. (C) 1999 Society of Chemical Industry.