OUTCOME OF NEONATES WITH ELECTROGRAPHICALLY IDENTIFIED SEIZURES, OR AT RISK OF SEIZURES

A prospective study was conducted to investigate survival at 1 month a nd survival and developmental outcome at 1 year in a cohort of 53 neon ates either suspected of or at risk of having seizures, For all patien ts, presence of seizures, diagnoses, and structural abnormalities were identified, If seizures were present, seizure variables were quantifi ed, Correlations between neonatal parameters and subsequent outcome we re investigated, Forty-three patients survived the first month of life , Background EEG was the only significant predictor of survival at 1 m onth, Three patients died after 1 month, and 2 of the three had extrem ely depressed interictal EEGs. Development outcome at 1 year was deter mined for all available surviving patients. Abnormal findings from bra in imaging studies and number of independent electrographic seizure fo ci were correlated with some aspects of outcome at 1 year. No other co rrelations were identified between neonatal parameters and outcome. (C ) 1997 by Elsevier Science Inc.