THE EFFECTS OF CYCLO-3-FORT TREATMENT ON HEMORHEOLOGICAL DISTURBANCESDURING A PROVOKED VENOUS STASIS IN PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY

Venous insufficiency is well known to be accompanied by blood flow dis turbances. In previous studies, we have already pointed-out the presen ce of hemorheological abnormalities in this disease. The present study is devoted towards the evaluation of hemorheologic and hemodynamic ch anges induced by a provoked venous stasis in either normal subjects an d patients with chronic venous insufficiency without varicose veins (C VI). The provoked venous stasis consisted of a compression by a cuff a t 100 mmHg during 10 minutes. Then, using the same procedure, we have studied the effects of Cycle 3 Fort versus placebo. The results show a significant red blood cell (RBC) hyperaggregation in patients. The ma in emphasis was however on the deleterious effect of venous stasis on RBC aggregation in patients. In regards to Cycle 3 Fort, it is shown t o reduce the deleterious effects of the venous stasis after a 4-weeks treatment. By contrast, hemodynamic parameters remained unchanged. The se hemorheologic improvements might be related to intrinsic factors of blood viscosity, seeing that we have no hemodynamic effect.