Evoked otoacoustic emissions have been shown to be suppressed by sounds app
lied in the contralateral ear and this effect can be largely explained by t
he involvement of medial olivocochlear efferent fibers. Thus, EOAE recordin
g during contralateral stimulation provides a non-invasive means of investi
gating auditory efferent system functioning in humans. The question remains
, however, as to whether this test provides a tool, which could be useful i
n a variety of clinical applications. This review describes current clinica
l applications for this test, showing that it may prove useful for improvin
g identification of retrocochlear pathologies. Some new areas are also iden
tified. Methodological topics are discussed and suggestions for maximizing
the value of this test are proposed.