B. Lubec et al., DISTRIBUTION AND DISAPPEARANCE OF THE RADIOLABELED CARBON DERIVED FROM L-ARGININE AND TAURINE IN THE MOUSE, Life sciences, 60(26), 1997, pp. 2373-2381
Citations number
34
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
L-arginine and taurine are still in the center of physiological and ph
armacological research. Although the fate of nitrogen of both compound
s and of the S-35-taurine is well-documented, the fate of the carbon s
keleton has not been elucidated yet. We studied the organ distribution
of C-14 arginine and C-14 taurine over time in the mouse using whole
body autoradiography with densitometric image analysis. We describe di
fferent organ distribution patterns. Kidney, heart, lung, the Harderia
n gland, the central nervous system, intestine and testis showed a com
parable pattern of arginine disappearance in contrast to rapid disappe
arance in the salivary gland and the accumulation pattern in bone and
spleen. Data on C-14 taurine of liver, kidneys, lung, testis and Harde
rian gland resembled the arginine pattern; Accumulation of taurine car
bon was found in salivary gland, bone, intestine, heart and brain. Our
studies challenge and demand further related studies to obtaining mor
e information on the fate of the carbon skeleton of these amino acids.