DISTRIBUTION AND DISAPPEARANCE OF THE RADIOLABELED CARBON DERIVED FROM L-ARGININE AND TAURINE IN THE MOUSE

Citation
B. Lubec et al., DISTRIBUTION AND DISAPPEARANCE OF THE RADIOLABELED CARBON DERIVED FROM L-ARGININE AND TAURINE IN THE MOUSE, Life sciences, 60(26), 1997, pp. 2373-2381
Citations number
34
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
ISSN journal
00243205
Volume
60
Issue
26
Year of publication
1997
Pages
2373 - 2381
Database
ISI
SICI code
0024-3205(1997)60:26<2373:DADOTR>2.0.ZU;2-#
Abstract
L-arginine and taurine are still in the center of physiological and ph armacological research. Although the fate of nitrogen of both compound s and of the S-35-taurine is well-documented, the fate of the carbon s keleton has not been elucidated yet. We studied the organ distribution of C-14 arginine and C-14 taurine over time in the mouse using whole body autoradiography with densitometric image analysis. We describe di fferent organ distribution patterns. Kidney, heart, lung, the Harderia n gland, the central nervous system, intestine and testis showed a com parable pattern of arginine disappearance in contrast to rapid disappe arance in the salivary gland and the accumulation pattern in bone and spleen. Data on C-14 taurine of liver, kidneys, lung, testis and Harde rian gland resembled the arginine pattern; Accumulation of taurine car bon was found in salivary gland, bone, intestine, heart and brain. Our studies challenge and demand further related studies to obtaining mor e information on the fate of the carbon skeleton of these amino acids.