EFFECTS OF FLUOXETINE ON THE IMMUNOSUPPRESSIVE RESPONSE TO STRESS IN MICE

Authors
FREIREGARABAL M NUNEZ MJ LOSADA C PEREIRO D RIVEIRO MP GONZALEZPATINO E MAYAN JM REYMENDEZ M
Citation
M. Freiregarabal et al., EFFECTS OF FLUOXETINE ON THE IMMUNOSUPPRESSIVE RESPONSE TO STRESS IN MICE, Life sciences, 60(26), 1997, pp. 403-413
Citations number
67
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
60
Issue
26
Year of publication
1997
Pages
403 - 413
Database
ISI
SICI code
0024-3205(1997)60:26<403:EOFOTI>2.0.ZU;2-0
Abstract
Mice exposed to a chronic auditory stressor and treated with fluoxetin e (5 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, and in peripheral T lymphocyte population. Th e blastogenic response of spleen lymphoid cells and the delayed type h ypersensitivity response (DTH) to sheep red blood cells (SRBC) were al so assessed and fluoxetine was found to partially reverse the inhibito ry effect of stress on both parameters. (C) 1997 Elsevier Science Inc.