Mapping phorbol ester binding domains of protein kinase C (PKC): The design, synthesis and biological activity of novel phorbol ester dimers

Authors
Wender, PA Koehler, MFT Wright, DL Irie, K
Citation
Pa. Wender et al., Mapping phorbol ester binding domains of protein kinase C (PKC): The design, synthesis and biological activity of novel phorbol ester dimers, SYNTHESIS-S, 1999, pp. 1401-1406
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Year of publication
1999
Pages
1401 - 1406
Database
ISI
SICI code
0039-7881(1999):<1401:MPEBDO>2.0.ZU;2-B
Abstract
The design and synthesis of a new class of protein kinase C (PKC) activator s, phorbol ester dimers, is described. These dimers were found to bind to a nd activate PKC with affinities depending dramatically on their tether leng th and composition. In two cases, the binding affinities of these novel com pounds exceeded that of phorbol dibutyrate.