Chemoenzymatic synthesis of key epothilone fragments

Authors
Machajewski, TD Wong, CH
Citation
Td. Machajewski et Ch. Wong, Chemoenzymatic synthesis of key epothilone fragments, SYNTHESIS-S, 1999, pp. 1469-1472
Citations number
23
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Year of publication
1999
Pages
1469 - 1472
Database
ISI
SICI code
0039-7881(1999):<1469:CSOKEF>2.0.ZU;2-C
Abstract
The rapid and efficient chemoenzymatic synthesis of key intermediates for t he syntheses of the epothilones is reported. The key enzymatic steps of the synthesis are a lipase resolution of an alpha-methyl ester and the 2-deoxy ribose-5-phosphate aldolase catalyzed condensation of acetaldehyde and L-la ctaldehyde.