Total synthesis and protein kinase activity of C(7) methyl derivatives of K252a

Authors
Wood, JL Petsch, DT Stoltz, BM Hawkins, EM Elbaum, D Stover, DR
Citation
Jl. Wood et al., Total synthesis and protein kinase activity of C(7) methyl derivatives of K252a, SYNTHESIS-S, 1999, pp. 1529-1533
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Year of publication
1999
Pages
1529 - 1533
Database
ISI
SICI code
0039-7881(1999):<1529:TSAPKA>2.0.ZU;2-E
Abstract
Recent efforts in these laboratories have resulted in the development of a synthetic approach to C(7) alkyl analogs in the K252a class of indolocarbaz ole natural products. Synthesis of 7-(R)-methyl K252a (3a) and 7-(S)-methyl K252a (3b) will be described along with their activity against protein tyr osine kinases.