Pa. Revell et al., BIOLOGICAL REACTION TO DEBRIS IN RELATION TO JOINT PROSTHESES, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 211(2), 1997, pp. 187-197
Bone loss induced by the inflammatory response to wear particles is a
major cause of long-term failure of total joint replacement. This revi
ew describes the cellular reaction occurring in response to these part
icles and what is currently known about the inflammatory mechanisms co
ntributing to bone resorption.