Thermochemical study on the growth metabolism of human promyelocytic leukemia HL-60 cells inhibited by water-soluble metalloporphyrins

By using an LKB 2277 Thermal Activity Monitor, the thermogenesis curves of human promyelocytic leukemia HL-60 cells growth were determined. It was fou nd that the heat production rate grew almost exponential during the first 1 0 h. When treated by two series of water-soluble metalloporphyrins, the gro wth metabolism of HL-60 cells can be suppressed. The extent of inhibitory e ffect as judged from the multiplication rate constant, k, varied with diffe rent porphyrins. From these data, it was found that these water-soluble met alloporphyrins can inhibit the growth metabolism of cancer cells even if th ere is no light. (C) 1999 Published by Elsevier Science B.V. All rights res erved.