F. Vermiglio et al., Post-Chernobyl increased prevalence of humoral thyroid autoimmunity in children and adolescents from a moderately iodine-deficient area in Russia, THYROID, 9(8), 1999, pp. 781-786
Circulating thyroglobulin antibodies (TgAb) and thyroperoxidase antibodies
(TPOAb) were measured in 143 iodine-deficient children, 5 to 15 years of ag
e, from the Region of Tula, Russia, who had been moderately contaminated af
ter the Chernobyl disaster (37-185 GBq/km(2) of caesium-137, [group A]) and
in 40 sex- and age-matched subjects from an uncontaminated neighboring are
a (<3.7 GBq/km(2) of caesium-137, [group B]). Increased thyroid size at son
ography was found in 41% and in 45% subjects from group A and group B, resp
ectively, associated with supranormal thyrotropin (TSH) values in 7.7% of g
roup A and 7.5% of group B, without differences in average serum free thyro
xine (FT4), free triiodothyronine (FT3) and TSH, Serum thyroperoxidase anti
body (TPOAb)-associated or not with thyroglobulin-antibody (TgAb) as detect
ed in 18.9% of children and adolescents from group A, about four-fold highe
r than in group B (5%, Fischer's exact test p < 0.05). A 24% frequency was
found in subjects whose age, at the moment of the disaster was 0-72 months
or were in utero, but the frequency was about 7%, similar to that in group
B, in those who had not yet been conceived at that time. Less than half of
antibody-positive group A children were hyperthyrotropinemic, whereas no gr
oup B subclinical hypothyroid subject was antibody-positive, thus excluding
the autoimmune etiology of the subclinical thyroid failure; more likely it
is attributable to iodine malnutrition. The high prevalence of humoral thy
roid autoimmunity phenomena in the investigated area suggests a combined ro
le of iodine malnutrition in enhancing the effects of short lived iodine is
otopes, particularly evident in pubertal individuals conceived or born imme
diately before the Chernobyl disaster.