Overwhelming trial evidence indicates that the treatment of hypertension is
beneficial, but in practice, less than 50% of treated hypertensive subject
s have blood pressure well controlled. The success of treatment relies on a
cceptance by the patient. Treatment acceptance may be affected by the effic
acy and tolerability of drug therapy, its effects on quality of life, and o
ther important but less well-recognized influences such as the expectations
and preconceived ideas of the physician and the patient. This report brief
ly reviews the factors affecting patient concordance with antihypertensive
treatment and the role these Factors play in the development of an integrat
ed treatment plan. Nonconcordance with drug therapy is common: Only one thi
rd of patients always lake treatment, one third take it sometimes, and one
third never take their prescribed medication. With poor concordance, contro
l of blood pressure and the consequent benefits are less likely to be reali
zed. The factors that influence concordance are ill understood. Although dr
ug side effects and convenience of dosing regimens are contributors, the at
titudes of patients, physicians, and their interactions are likely to be of
considerable importance. Concordance may be improved by involving the pati
ent in the treatment plan, setting explicit targets, following a clear trea
tment pion, motivating the patient to comply with treatment, paying attenti
on to the concerns and particular needs of the individual patient, and by e
nsuring frequent contacts between patients and health care professions. Suc
cessful integrated approaches to the management of hypertension must addres
s all the factors that affect treatment acceptance.