Wolff-Parkinson-White syndrome is the most common form of ventricular preex
citation. Understanding this syndrome is fundamental for anyone interested
in learning about arrhythmias. This review addresses (1) the historic seque
nce of events that led to the understanding of this syndrome; (2) the patho
logic, embryologic, and electrophysiologic properties of accessory pathways
, (3) the epidemiology and genetics of this syndrome; (4) the clinical diag
nosis of this syndrome, with special emphasis on the arrhythmias that patie
nts with ventricular preexcitation are predisposed to; and (5) the therapy
for patients with Wolff-Parkinson-White syndrome.