Notalgia paresthetica associated with multiple endocrine neoplasia type IIA (Sipple's Syndrome): A report of 3 cases

Introduction. Notalgia paresthetica is an isolated sensory mononeuropathy P atients have a pruritus in the mid-upper back. Its association with multipl e endocrine neoplasia type IIA has been reported in a few cases. We report three cases of this association. Case reports. Case n degrees 1: A 45 year-old woman had multiple endocrine neoplasia type IIA with a medullary thyroid carcinoma and a primary hyperpa rathyroidism; she had a mid-upper back pigmented lesion. Histological exami nation showed dermal melanosis and deposits of amyloid in the dermis. Case n degrees 2: A woman had a multiple endocrine neoplasia type IIA which was diagnosed at the age of 60; she had a surgical treatment for a pheochromocy toma, a medullary thyroid carcinoma, and a primary hyperparathyroidism; she had dermatological examination for a pruriginous lesion of the mid-upper b ack. Case n degrees 3: The daughter of the patient n degrees 2. had had a s urgical cure for a medullary thyroid carcinoma and a pheochromocytoma at th e age of 31; she had a papulous and-pruriginous lesion in the left scapular area. Her daughter and her sister had a multiple endocrine neoplasia type IIA, without notalgia paresthetica. Discussion. Notalgia paresthetica is a benign cutaneous disorder which can be associated with multiple endocrine neoplasia type IIA, it can be conside red that notalgia paresthetica is an early clinical marker of multiple endo crine neoplasia type IIA,. Patients with a familial history of notalgia par esthetica or with an onset of notalgia paresthetica in childhood should be screened for multiple endocrine neoplasia type IIA,. Patients with multiple endocrine neoplasia must also been screened for notalgia paresthetica beca use its finding is an argument for a familial form of multiple endocrine ne oplasia type IIA,. Dermatologists should be aware of this association.