Stability of cefepime in peritoneal dialysis solution

OBJECTIVE: To determine the stability of cefepime in peritoneal dialysis so lution. DESIGN: Cefepime HCl was added to premade bags of Delflex peritoneal dialys is solution with 1.5% dextrose to produce a cefepime concentration of appro ximately 100 mu g/mL. Peritoneal dialysis solution bags were stored at 4, 2 5, and 37 degrees C to simulate refrigeration, room temperature, and body t emperature, respectively. Samples were drawn at scheduled times up to 336, 168, and 48 hours, respectively, after the addition of cefepime HCl. Cefepi me concentrations were measured by HPLC. SETTING: This study was performed at a university-affiliated tertiary care hospital. OUTCOME MEASURES: If the mean concentration of the samples at a given time and condition was >90% of the initial concentration cefepime was considered stable at that time and condition. RESULTS: The mean HPLC results for samples drawn at each time and condition were all >90%. CONCLUSIONS: Cefepime is stable in peritoneal dialysis solution with dextro se 1.5% for 14 days refrigerated, seven days at room temperature, and 48 ho urs at 37 degrees C.