UTOPIA (UTilities for OPtimizing Insulin Adjustment) is a prototype co
mputer system proposed to support home data analysis and therapy recom
mendations for the individual patient. The paper describes methods of
analysis and their incorporation into an overall system design that ma
tches the iterative practices at the physician-patient consultation fr
om visit to visit. Four modules support home data display and comparis
on with clinical measurements; extraction of blood glucose trends and
daily cycles using time series analysis, learning relationships betwee
n insulin adjustments and changes in time series patterns via a parame
tric, linear systems model; and advice generation by solving the linea
r equation for candidate insulin adjustments. Concepts and methods are
placed in context, with a discussion of comparable and related resear
ch.