INDUCTION OF TOLERANCE AND MOSSY FIBER NEUROPEPTIDE-Y EXPRESSION IN THE CONTRALATERAL HIPPOCAMPUS FOLLOWING A UNILATERAL INTRAHIPPOCAMPAL KAINIC ACID INJECTION IN THE RAT

Authors
ELBAHH B LURTON D SUNDSTROM LE ROUGIER A
Citation
B. Elbahh et al., INDUCTION OF TOLERANCE AND MOSSY FIBER NEUROPEPTIDE-Y EXPRESSION IN THE CONTRALATERAL HIPPOCAMPUS FOLLOWING A UNILATERAL INTRAHIPPOCAMPAL KAINIC ACID INJECTION IN THE RAT, Neuroscience letters, 227(2), 1997, pp. 135-139
Citations number
30
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
227
Issue
2
Year of publication
1997
Pages
135 - 139
Database
ISI
SICI code
0304-3940(1997)227:2<135:IOTAMF>2.0.ZU;2-S
Abstract
We have previously reported an ectopic expression of neuropeptide-Y (N PY) immunoreactivity in messy fibres (MFs) in the contralateral hippoc ampus following a unilateral intrahippocampal (IH) injection of kainic acid (KA). In the present study we report that, in addition to MF NPY expression, unilateral IH KA injections also induce tolerance towards a subsequent intracerebroventricular (ICV) contralateral KA injection , resulting in a reduction in the number of overt seizures and degree of cell loss. (C) 1997 Elsevier Science Ireland Ltd.