Mg. Banwell et al., Synthesis, X-ray crystal structure and tubulin-binding properties of a benzofuran analogue of the potent cytotoxic agent combretastatin A4, AUST J CHEM, 52(8), 1999, pp. 767-774
The benzofuran (4), a ring-fused analogue of the potent antimitotic agent c
ombretastatin A4 (1), has been prepared by a convergent route involving 5-e
ndo-dig iodocyclization of o-hydroxytolan (5) as the key step. Compound (4)
, which has been characterized crystallographically as well as spectroscopi
cally, is inactive as a tubulin-binding agent.