Tomato consumption modulates oxidative DNA damage in humans

Consumption of a single serving of tomatoes by healthy human volunteers was sufficient 60 alter levels of oxidative DNA base damage in white cell DNA within 24 h. Levels of the mutagenic oxidized purine base 8-hydroxyguanine decreased, especially in those subjects whose initial levels of this base w ere higher than the mean. However, total DNA base damage remained unchanged since levels of 8-hydroxyadenine rose. The ability of tomato consumption t o modulate oxidative DNA damage in the short term may indicate why daily co nsumption of fruits and vegetables is beneficial in decreasing cancer incid ence. (C) 1999 Academic Press.