El. Gujaeva et al., Different pathways for mitogenic and enzyme induction signal transduction by cytochrome P450 inducers, BIOCHEM-MOS, 64(8), 1999, pp. 929-932
The correlation between enzyme induction and cell proliferation caused by i
nducers of xenobiotic metabolizing enzymes was studied using a cell culture
expressing a constitutive level of cytochrome P450 (hepatoma McA RH 7777)
and a cell culture in which cytochrome P450 was absent (hepatoma 27). In he
patoma 27 cells, the inducers did not induce the synthesis of xenobiotic :m
etabolizing enzymes but stimulated cell proliferation. Thus, the processes
of signal transduction:for enzyme induction and for cell proliferation by t
he inducers are different.