Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase

Authors
Rumsby, G Cregeen, DP
Citation
G. Rumsby et Dp. Cregeen, Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase, BBA-GENE ST, 1446(3), 1999, pp. 383-388
Citations number
10
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1446
Issue
3
Year of publication
1999
Pages
383 - 388
Database
ISI
SICI code
0167-4781(19990903)1446:3<383:IAEOAC>2.0.ZU;2-N
Abstract
The isolation and expression of a human liver cDNA encoding a 40-kDa protei n with glyoxylate and hydroxypyruvate reductase activities is described. Th e cDNA (GLXR) is 1235 bp and consists of a predicted open reading frame of 987 bp with a 225-bp 3'-untranslated region. The 328-amino acid protein has partial sequence similarity to hydroxypyruvate and glyoxylate reductases f rom a variety of plant and microbial species. (C) 1999 Elsevier Science B.V . All rights reserved.