Induction of cellular immunosuppression by the human papillomavirus type 16 E7 oncogenic protein

Authors
Le Buanec, H Lachgar, A D'Anna, R Zagury, JF Bizzini, B Bernard, J Ittele, D Hallez, S Giannouli, C Burny, A Zagury, D
Citation
H. Le Buanec et al., Induction of cellular immunosuppression by the human papillomavirus type 16 E7 oncogenic protein, BIOMED PHAR, 53(7), 1999, pp. 323-328
Citations number
24
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOMEDICINE & PHARMACOTHERAPY
ISSN journal
07533322 → ACNP
Volume
53
Issue
7
Year of publication
1999
Pages
323 - 328
Database
ISI
SICI code
0753-3322(199908)53:7<323:IOCIBT>2.0.ZU;2-1
Abstract
The human papillomavirus type 16 (HPV-16) E7 oncogenic protein is found in the culture supernmatant of SiHa cells, a cervical carcinoma cell line. Ext racellular E7 protein, acting as a viral toxin in human immune cells, induc es the overproduction of the immune suppressive IFN alpha cytokine by APCs, and inhibits the T-cell response to recall and allogenic antigens. These e ffects should be taken into account for the design of anti-human cervical c arcinoma vaccines. (C) 1999 Elsevier, Paris.