Fecal excretion pattern of bile acids in rats fed high fat diets and neomycin in induced colon tumorigenesis

Authors
Panda, SK Broitman, SA
Citation
Sk. Panda et Sa. Broitman, Fecal excretion pattern of bile acids in rats fed high fat diets and neomycin in induced colon tumorigenesis, BIOORG MED, 9(17), 1999, pp. 2459-2462
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
17
Year of publication
1999
Pages
2459 - 2462
Database
ISI
SICI code
0960-894X(19990906)9:17<2459:FEPOBA>2.0.ZU;2-L
Abstract
Neomycin augments colon tumorigenesis in 1,2 - dimethylhydrazine treated ra ts fed polyunsaturated fat diet and decreases fecal cholic acid excretion, while it inhibits tumorigenesis with increased cholic acid and decreased de oxycholic acid excretions in rats fed high cholesterol diet. Participation of other fecal bile acids seems to be insignificant in relation to colon ca rcinogenesis. (C) 1999 Elsevier Science Ltd. All rights reserved.