2,7-Diazabicyclo[3.3.0]octanes as novel h5-HT1D receptor agonists

Authors
Russell, MGN Beer, MS Stanton, JA Sohal, B Mortishire-Smith, RJ Castro, JL
Citation
Mgn. Russell et al., 2,7-Diazabicyclo[3.3.0]octanes as novel h5-HT1D receptor agonists, BIOORG MED, 9(17), 1999, pp. 2491-2496
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
17
Year of publication
1999
Pages
2491 - 2496
Database
ISI
SICI code
0960-894X(19990906)9:17<2491:2ANHRA>2.0.ZU;2-C
Abstract
The conformational restriction of a (benzylamino)methyl substituted pyrroli dine to form 2,7-diazabicyclo[3.3.0]octanes has led to a series of compound s with high affinity at the h5-HT1D receptor as well as dramatically increa sed concentrations in the hepatic portal vein following oral administration . (C) 1999 Published by Elsevier Science Ltd. All rights reserved.