Wl. Cody et al., The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1, BIOORG MED, 9(17), 1999, pp. 2497-2502
Utilizing X-ray crystallography and molecular modeling, highly potent and s
elective peptidomimetic thrombin inhibitors have been designed containing a
rigid piperazinedione template. The synthesis and biological activity of t
hese compounds will be described. (C) 1999 Elsevier Science Ltd. All rights
reserved.