The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1

Authors
Cody, WL Cai, CM Doherty, AM Edmunds, JJ He, JX Narasimhan, LS Plummer, JS Rapundalo, ST Rubin, JR Van Huis, CA St-Denis, Y Winocour, PD Siddiqui, MA
Citation
Wl. Cody et al., The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1, BIOORG MED, 9(17), 1999, pp. 2497-2502
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
17
Year of publication
1999
Pages
2497 - 2502
Database
ISI
SICI code
0960-894X(19990906)9:17<2497:TDOPAS>2.0.ZU;2-J
Abstract
Utilizing X-ray crystallography and molecular modeling, highly potent and s elective peptidomimetic thrombin inhibitors have been designed containing a rigid piperazinedione template. The synthesis and biological activity of t hese compounds will be described. (C) 1999 Elsevier Science Ltd. All rights reserved.