The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 2

Authors
Cody, WL Augelli-Szafran, CE Berryman, KA Cai, CM Doherty, AM Edmunds, JJ He, JX Narasimhan, LS Penvose-Yi, J Plummer, JS Rapundalo, ST Rubin, JR Van Huis, CA Leblond, L Winocour, PD Siddiqui, MA
Citation
Wl. Cody et al., The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 2, BIOORG MED, 9(17), 1999, pp. 2503-2508
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
17
Year of publication
1999
Pages
2503 - 2508
Database
ISI
SICI code
0960-894X(19990906)9:17<2503:TDOPAS>2.0.ZU;2-C
Abstract
Potent and selective thrombin inhibitors have been prepared with a piperazi nedione template and L-amino acids. Likewise, incorporation of D-amino acid s led to potent inhibitors with a novel mode of binding. Herein, the struct ure activity relationships and structural aspects of these compounds will b e described. (C) 1999 Elsevier Science Ltd. All rights reserved.