Synthesis and sar of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase

Authors
Greenlee, ML Laub, JB Balkovec, JM Hammond, ML Hammond, GG Pompliano, DL Epstein-Toney, JH
Citation
Ml. Greenlee et al., Synthesis and sar of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase, BIOORG MED, 9(17), 1999, pp. 2549-2554
Citations number
31
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
17
Year of publication
1999
Pages
2549 - 2554
Database
ISI
SICI code
0960-894X(19990906)9:17<2549:SASOTA>2.0.ZU;2-1
Abstract
Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step . (C) 1999 Elsevier Science Ltd. All rights reserved.