New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D-2 template

Authors
Mewshaw, RE Nelson, JA Shah, US Shi, XJ Mazandarani, H Coupet, J Marquis, K Brennan, JA Andree, TH
Citation
Re. Mewshaw et al., New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D-2 template, BIOORG MED, 9(17), 1999, pp. 2593-2598
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
17
Year of publication
1999
Pages
2593 - 2598
Database
ISI
SICI code
0960-894X(19990906)9:17<2593:NGDA7H>2.0.ZU;2-0
Abstract
The synthesis of several bioisosteric analogs based on the 3-OH-phenoxyethy lamine dopamine D-2 agonist template (i.e., 3) is described. The benzimidaz ol-2-ones and benzthioimidazol-2-ones (7-10) and 2-trifluoromethyl-benzimid azole (13) were observed to have excellent affinity for the Dp receptor. (C ) 1999 Elsevier Science Ltd. All rights reserved.