alpha-Chymotrypsin-catalyzed enantioselective amidation of chiral amines using an N-protected amino acid carbamoylmethyl ester as acyl donor

Authors
Miyazawa, T Yabuuchi, N Yanagihara, R Yamada, T
Citation
T. Miyazawa et al., alpha-Chymotrypsin-catalyzed enantioselective amidation of chiral amines using an N-protected amino acid carbamoylmethyl ester as acyl donor, BIOTECH LET, 21(9), 1999, pp. 725-728
Citations number
6
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
BIOTECHNOLOGY LETTERS
ISSN journal
01415492 → ACNP
Volume
21
Issue
9
Year of publication
1999
Pages
725 - 728
Database
ISI
SICI code
0141-5492(199909)21:9<725:AEAOCA>2.0.ZU;2-2
Abstract
alpha-Chymotrypsin catalyzed the highly enantioselective amidation of chira l amines such as 1-(1-naphthyl)ethylamine using N-benzyloxycarbonyl-(S)-phe nylalanine carbamoylmethyl ester as acyl donor (E = 25-660) in acetonitrile with low water content.