Bacterial epoxide hydrolases of opposite enantiopreference

Authors
Krenn, W Osprian, I Kroutil, W Braunegg, G Faber, K
Citation
W. Krenn et al., Bacterial epoxide hydrolases of opposite enantiopreference, BIOTECH LET, 21(8), 1999, pp. 687-690
Citations number
15
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
BIOTECHNOLOGY LETTERS
ISSN journal
01415492 → ACNP
Volume
21
Issue
8
Year of publication
1999
Pages
687 - 690
Database
ISI
SICI code
0141-5492(199908)21:8<687:BEHOOE>2.0.ZU;2-T
Abstract
Epoxide hydrolases of matching opposite enantiopreference were found among various Actinomyces spp. While (S)-2,2-disubstituted oxiranes were hydrolyz ed by Rhodococcus and Nocardia spp., several strains of methylotrophic bact eria, such as Mycoplana rubra and Methylobacterium spp., exhibited a prefer ence for the (R)-enantiomers. Thus, the stereochemical course of the reacti on can be controlled by a simple choice of the appropriate enzyme source.